Demonstrate the effectiveness of oral fluorescein in pediatric patients and evaluate the retina of patients treated with intravitreal anti-angiogenic agents for Retinopathy of Prematurity (ROP) using Ultra-Wide Field Oral Fluorescein Angiography.
After ophthalmological evaluation with ROP diagnosis and the respective antiangiogenic treatment, fundus photography was performed on patients of two months olds and older using Optos Silverstone, we conducted oral fluorescein angiography following fasting of minimum of 2 hours and antihistamine administration. Images were analyzed by retina and vitreous specialists along with an ophthalmology resident.
85.7% exhibited avascular zones and 81% showing arteriovenous anastomoses. Neovascular leakage was observed in 19% and confirmed by angiography, but undetected clinically. No adverse effects occurred during the study or the six months that were being observed.
Oral fluorescein angiography is recommended for pediatric ROP assessment and follow-up. Its non-invasiveness makes it appealing for broader clinical use, potentially extending to adult populations to mitigate catheterization-related complications.
The authors have no financial interests in any material discussed in this article. There are no conflicts of interest to disclose.